Substituted guanidines having high binding to the sigma receptor and the use thereof
AssigneeState of Oregon, Oregon Health Sciences University of Oregon
InventorsJohn F. W. Keana, Eckard Weber
Life of this patent
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Abstract
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
Claims4
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound selected from N-(2-methyl-4-azidophenyl)-N'-(2-methylphenyl)guanidine, N,N'-di(o-methylbenzyl)guanidine, N,N'-di(o-methylbenzyl)guanidine, and N,N'-dibenzylguanidine.
Dependencies are inferred from the claim text.