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US 5,478,853 AGranted
Thazolidinedione compounds
AssigneeAdir et Compagnie
InventorsGilbert Regnier, Yves Charton, Jacques Duhault, Joseph Espinal
Life of this patent
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Abstract
The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes. A compound disclosed is: 5-{4-[2-(2-methoxy-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dione.
Claims7
A thiazolidine dione compound selected from the following:
- 5-{4-[2-(2-methoxy-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(4-hydroxy-3,5-di-tert-butylbenzamido)ethyl]benzyl}thiazolidi ne-2,4-dione,
- (R,S)-5-{4-[2-(salicyloylamino)ethyl]benzyl}thiazolidine-2,4-dione,
- 5-{4-[2-(phthalimido)ethyl]benzyl}thiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(2,5-dimethoxybenzamido)ethyl]benzyl}thiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(4-methoxyphenylsulphamoyl)ethyl]benzyl}thiazolidine-2,4-dion e,
- (R,S)-5-{4-[2-(3-trifluoromethylbenzamido)ethyl]benzyl}thiazolidine-2,4-dio ne,
- (R,S)-5-{4-[2-(3,4-dichlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(2-hydroxy-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-di one,
- (R,S)-5-{4-[2-(2-amino-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dion e,
- (R,S)-5-{4-[2-(2-dimethylamino-5-chlorobenzamido)ethyl]benzyl}thiazolidine- 2,4-dione,
- (R,S)-5-{4-[2-(2-dimethylaminobenzamido)ethyl]benzyl}thiazolidine-2,4-dione
- (R,S)-5-{4-[2-(2-piperidino-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4 -dione,
- (R,S)-5-{4-[3-(2-methoxy-5-chlorobenzamido)propyl]benzyl}thiazolidine-2,4-d ione,
- (R,S)-5-{4-[2-(2-methoxy-5-trifluoromethylbenzamido)ethyl]benzyl}thiazolidi ne-2,4-dione,
- (R,S)-5-{4-[(5-chloro-2-methoxybenzamido)methyl]benzyl}thiazolidine-2,4-dio ne,
- (R,S)-5-{4-[1-hydroxy-2-(5-chloro-2-methoxybenzamido)ethyl]benzyl}thiazolid ine-2,4-dione,
- (R,S)-5-{4-[2-(3-(3,4-dimethoxyphenyl)prop-2-enoylamino)ethyl]benzyl}thiazo lidine-2,4-dione,
- (R,S)-5-{4-[2-(3-(3,4-methylenedioxyphenyl)prop-2-enoylamino)ethyl]benzyl}t hiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(2,2-(2,6-dimethylphenyl)acetylamino)ethyl]benzyl}thiazolidin e-2,4-dione,
- (R,S)-5-{4-[2-(3-(4-hydroxy-3-methoxyphenyl)prop-2-enoylamino)ethyl]benzyl} thiazolidine-2,4-dione,
- (R,S)-5-{4-[2-(3-(4-acetoxy-3-methoxyphenyl)prop-2-enoylamino)ethyl]benzyl} thiazolidine-2,4-dione.
19 more elements
Dependencies are inferred from the claim text.