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US 5,478,846 AGranted
1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsAlbert A. Carr, Richard C. Dage, Thaddeus R. Nieduzak, John E. Koerner, Tung Li
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Abstract
The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents.
Claims30
A compound of the formula:
- ##STR8## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, or OH;
- R.sub.1 is hydrogen or C.sub.1-4 alkyl;
- X is represented by CO or CHOH;
- m is an integer from 1-3;
- n is an integer from 1-3;
- and Alk is a C.sub.1-4 alkyl;
- and the pharmaceutically acceptable addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.