Method of using aminocoumaran derivatives for treating cerebrovascular diseases
AssigneeTakeda Chemical Industries, Ltd.
InventorsTetsuya Aono, Shigenori Ohkawa, Takayuki Doi
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AssigneeTakeda Chemical Industries, Ltd.
InventorsTetsuya Aono, Shigenori Ohkawa, Takayuki Doi
Estimating the term…
A novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R.sup.3, R.sup.4 and R.sup.5 are an optionally acylated hydroxyl optionally substituted amino group, alkoxy group or aliphatic group, or two of R.sup.3, R.sup.4 and R.sup.5 may be linked together to form a carbocyclic group; R.sup.6 and R.sup.7 are an aliphatic group and at least: one of them has a methylene group at the .alpha.-position; R.sup.8 and R.sup.9 are a hydrogen atom or an aliphatic group or aromatic group, or a salt thereof is useful for medicines for treating various diseases such as arterial sclerosis, hepatopathy, cerebrovascular diseases and the like.
A method for treating cerebrovascular disease which comprises administering an effective amount of the compound of the formula (I) ##STR4## wherein R.sup.1 and R.sup.2 are the same or different and are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an optionally substituted aliphatic or an optionally substituted phenyl;
A method for treating cerebral edema which comprises administering an effective amount of the compound of the formula (I) ##STR5## wherein R.sup.1 and R.sup.2 are the same or different and are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an optionally substituted aliphatic or an optionally substituted phenyl;
Dependencies are inferred from the claim text.