4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof

A 4-amino(alkyl)cyclohexane-1-carboxamide compound of the formula (I) ##STR29## wherein:

• R.sup.1 and R.sup.2 are the same or different and each is hydrogen, alkyl, or cycloalkyl, cycloalkylalkyl, phenyl, aralkyl, piperidyl or pyrrolidinyl, which may have substituent on the ring, or a group of the formula ##STR30## wherein R is hydrogen, alkyl, --NR'R" (where R' and R" are the same or different and each is hydrogen, alkyl, aralkyl or phenyl),
• R.sup.0 is hydrogen, alkyl, aralkyl, phenyl, nitro or cyano, or
• R and R.sup.0 may combinedly form a heterocyclic ring which may have, in the ring, oxygen atom, sulfur atom or optionally substituted nitrogen atom, or
• R.sup.1 and R.sup.2 combinedly are alkylidene or phenylalkylidene, or
• R.sup.1 and R.sup.2 form, together with the nitrogen atom binding therewith, a heterocyclic ring which may have, in the ring, oxygen atom, sulfur atom or optionally substituted nitrogen atom;
• R.sup.3 and R.sup.4 are each hydrogen or alkyl;
• A is a single bond or alkylene;
• X is .dbd.C(R.sup.7)-- or .dbd.N--;
• R.sup.5 and R.sup.6 together are a group of the formula ##STR31## wherein Ra and Rb combinedly form an optionally hydrogenated 5- or 6-membered aromatic ring which may have, in the ring, at least one of nitrogen atom, sulfur atom and oxygen atom;
• R.sup.7 and R.sup.8 are the same or different and each is hydrogen, halogen, alkyl, alkoxy, aralkyl, haloalkyl, nitro, --NReRf {wherein Re and Rf are the same or different and each is hydrogen, alkyl, --COR.sup.9, --COOR.sup.9 ', --SO.sub.2 R.sup.9 ' (where R.sup.9 is hydrogen, alkyl, phenyl or aralkyl and R.sup.9 ' is alkyl, phenyl or aralkyl), or Re and Rf form, together with the nitrogen atom binding therewith, a heterocyclic ring which may have, in the ring, oxygen atom, sulfur atom or optionally substituted nitrogen atom}, cyano, azido, optionally substituted hydrazino, --COOR.sup.10, --CONR.sup.11 R.sup.12 (wherein R.sup.10-12 are each hydrogen, alkyl, phenyl or aralkyl);
• and
• n is 0 or 1;
• an isomer thereof or a pharmaceutically acceptable acid addition salt thereof.