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US 5,478,833 AGranted
Aconitine compounds and analgesic/anti-inflammatory agent containing the same
AssigneeSanwa Shoyaku Kabushiki Kaisha
InventorsMitsuo Murayama, Takao Mori
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Abstract
Novel aconitine compounds of the formula ##STR1## wherein the symbols are as defined in the description, as well as analgesic/anti-inflammatory agent containing them or salts thereof as active ingredient.
Claims2
An aconitine compound of the formula (1) or a salt thereof:
- ##STR5## wherein R.sub.1 and R.sub.2 are independently
- (i) hydrogen,
- (ii) an acyclic or or cyclic, saturated or unsaturated alkyl having 1-8 carbon atoms,
- (iii) an oxygen- or nitrogen-containing 5- or 6-membered heterocyclic group,
- (iv) acyl derived from an acyclo- or cyclo- aliphatic, aromatic or aromatic-aliphatic carboxylic acid, or
- (v) aralkyl;
- R.sub.3 and R.sub.4 are hydrogen or hydroxyl;
- R.sub.5 is hudrogen;
- R.sub.6 is a group forming carbonyl together with the carbon atom at the position 15;
- and
- R.sub.7 is methyl;
- provided that if R.sub.1 is benzoyl or anisoyl then R.sub.2 is acyl derived from an aliphatic or aromatic carboxylic acid.
9 more elements
Dependencies are inferred from the claim text.