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US 5,478,832 AGranted
Quinoline compounds
AssigneesThe Green Cross Corporation, Asahi Glass Company, Limited
InventorsYoshihisa Inoue, Hajime Ebisu, Naomichi Ishida, Norifumi Nakamura, Jun Sasaki, Takashi Okazoe, Yoshitomi Morizawa, Arata Yasuda
Life of this patent
Estimating the term…
Abstract
A quinoline compound represented by the formula (1) or a salt thereof: ##STR1## wherein the definition of each substituents are described in the specification, which have angiotensin II antagonism and hypotensive action and are useful as an agent for the prevention and treatment of cardiovascular system diseases such as hypertension, heart failure and the like.
Claims16
A quinoline compound represented by formula (1) or a salt thereof:
- ##STR15## wherein Q is a heterocyclic derivative moiety represented by formula (3) ##STR16## where R.sup.1 is a lower alkyl, halo lower alkyl, cyclo lower alkyl, alkenyl, alkoxy, alkoxy lower alkyl or alkylthio group;
- R.sup.2 and R.sup.3 may be the same or different and each represents a hydrogen atom, halogen atom, a lower alkyl, halo lower alkyl, cyclo lower alkyl, alkenyl or alkoxy group, C.sub.m F.sub.2m+1 --, --(CH.sub.2).sub.n R.sup.9 or --(CH.sub.2).sub.p COR.sup.10 ;
- R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl group, an alkoxy group or C.sub.m F.sub.2m+1 --;
- R.sup.5 is a hydrogen atom or a group selected from --COOH, --COOR.sup.11, --CONH.sub.2 and --CN;
- R.sup.6 is a group selected from --COOH, --COOR.sup.12, --CONH.sub.2, --CN, --NHSO.sub.2 CF.sub.3 and a C-bonding tetrazolyl group;
- R.sup.7 and R.sup.8 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an alkoxy group or C.sub.m F.sub.2m+1 --;
- X and Y may be the same or different and each represents CH or a nitrogen atom;
- R.sup.9 is a hydroxy group or an alkoxy group;
- R.sup.10 is a hydrogen atom, a hydroxy group, a lower alkyl group or an alkoxy group;
- R.sup.11 and R.sup.12 may be the same or different and each represents a lower alkyl, alkenyl, cyclo lower alkyl, aryl or aralkyl group;
- m is an integer of 1 to 6;
- n is an integer of 1 to 4;
- and p is an integer of 0 to 4.
10 more elements
Dependencies are inferred from the claim text.