Solution of sparfloxacin, its preparation and salt of which it is composed
AssigneeRhone-DPC Europe
InventorGuillaume Conrath
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Abstract
This invention relates to a pharmaceutical composition comprising sparfloxacin and a stable aqueous solution of sparfloxacin of the formula (I): ##STR1## comprising sparfloxacin, one or more polyhydroxymonocarboxylic acids, or lactone derivatives thereof, at least in a stoichiometric quantity with respect to sparfloxacin, and, optionally, an excess of said polyhydroxymonocarboxylic acid or another pharmaceutically acceptable acid for ensuring full solubilization of the salt so formed, not exceeding 5, and optionally an isotonic agent and/or other pharmaceutically acceptable additives.
Claims10
A stable aqueous solution of sparfloxacin of formula:
- ##STR3## which comprises:
- sparfloxacin
- at least one polyhydroxymonocarboxylic acid or its lactone derivative, at least in a stoichiometric quantity with respect to sparfloxacin,
- optionally an excess of the polyhydroxymonocarboxylic acid or another pharmaceutically acceptable acid intended to ensure a pH of complete solubilization of the salt thus formed, of less than or equal to 5,
- optionally, a tonicity regulator and/or other pharmaceutically acceptable adjuvant.
A salt of sparfloxacin with a polyhydroxymonocarboxylic acid selected from:
- lactobionic acid,
- glucoheptonic acid and
- ascorbic acid.
Dependencies are inferred from the claim text.