5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives

A compound of Formula (I) ##STR5## and pharmaceutically acceptable salts thereof, wherein Q represents piperidyl, morpholinyl, or piperazinyl bonded to the triazole ring by the heterocyclic nitrogen atom and optionally carrying a C.sub.1-4 alkyl substituent, or a group of the Formula S(O).sub.p R.sup.3, wherein

• P stands for 0,1 or 2, and
• R.sup.3 denotes straight or branched chained C.sub.1-8 alkyl, C.sub.2-6 alkenyl or phenyl-(C.sub.1-4 alkyl), which latter may optionally carry a halogen or a nitro substituent, or phenyl substituted by a nitro or a trifluoromethyl or a nitro and a trifluoromethyl;
• or a group of the Formula NR.sup.4 R.sup.5, wherein
• R.sup.4 and R.sup.5 each represent hydrogen, straight or branched C.sub.1-12 alkyl, C.sub.2-6 alkenyl, phenyl-(C.sub.1-4 alkyl) or di-(C.sub.1-4 alkyl)-amino-(C.sub.1-6 alkyl);
• R.sup.1 and R.sup.2 together form a group of the Formula (CH.sub.2).sub.n --Y--(CH.sub.2).sub.m, wherein Y stands for a CH.sub.2 group, a sulfur atom or a group of the Formula NR.sup.6, where R.sup.6 denotes phenyl-(C.sub.1-4 alkyl), and
• n is 1 or 4 and m is 1, 2, 3, 4 or 5 if Y stands for a CH.sub.2 group, or
• n is 1 or 2 and m is 1 or 2 if Y is a NR.sup.6 group, or
• n is 0 and m is 3 or n is 1 and m is 2 if Y is a sulfur group;
• stands for a group of the Formula NR.sup.7 R.sup.8 wherein R.sup.7 and
• R.sup.8 each represent hydrogen, C.sub.2-6 alkenyl, C.sub.3-8 cycloalkyl, adamantyl or phenyl-(C.sub.1-4 alkyl), which latter may optionally carry one to three substituent(s) selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, amino and nitro;
• (C.sub.1-4 alkyl)-amino-(C.sub.1-6 alkyl), di-(C.sub.1-4 alkyl)-amino-(C.sub.1-6 alkyl) or C.sub.1-6 alkyl, which latter may optionally be substituted by a hydroxy, amino, carboxy, morpholinocarbonyl, (4-(2-hydroxy-ethyl)piperazin-1-yl)-carbonyl, (C.sub.1-4 alkoxy)-carbonyl, piperidinyl, morpholinyl, piperazinyl, pyrrolidinyl or indol-3-yl;
• or
• R.sup.7 and R.sup.8 together form a group of the Formula (CH.sub.2)j--W--(CH.sub.2) k, wherein j and k each represent 1, or 2 or 3, and W stands for oxygen or a CH.sub.2 or CHOH group or a group of the Formula NR.sup.10, wherein R.sup.10 denotes hydrogen, C.sub.1-4 alkoxycarbonyl or C.sub.1-4 alkyl, which latter may optionally carry a substituent selected from the group consisting of hydroxy or phenyl;
• or a group of the Formula SR.sup.9 wherein
• R.sup.9 stands for C.sub.1-4 alkyl substituted by a (C.sub.1-4 alkoxy)-carbonyl group.