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US 5,478,818 AGranted
Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting composition containing the conjugate or estradiol derivative
AssigneeKureha Kagaku Kogyo Kabushiki Kaisha
InventorsKoichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
Life of this patent
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Abstract
Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3, which is useful a growth inhibiting agent.
Claims6
An estradiol derivative-alkylating agent conjugate of the formula (I'):
- ##STR10## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy;
- R.sup.2 is acyl or benzyl;
- m is an integer of 1 to 3;
- and n is an integer of 0 to 3.
1 more element
Dependencies are inferred from the claim text.