Antitumor substance BE-13793C derivatives
AssigneeBanyu Pharmaceutical Co., Ltd.
InventorsMasanori Okanishi, Daisuke Uemura, Seiichi Tanaka, Katsuhisa Kojiri, Akira Okura, Kohtaro Funaishi, Hiroyuki Suda
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Abstract
This invention relates to 12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione derivatives represented by the following general formula, pharmaceutically acceptable salts thereof, a method for preparation thereof and a use thereof: ##STR1## [wherein R.sup.1 denotes a monosaccharide group having 5 to 7 carbon atoms, and the hydroxyl groups of this monosaccharide group can be replaced by the same or different 1 to 3 groups selected from the group consisting of a hydrogen atom, lower alkyl group, lower alkylcarbonyloxy group and lower alkoxy group.]
Claims4
A BE-13793C derivative of the formula (I) or a pharmaceutically acceptable salt thereof ##STR4## wherein R' is a monosaccharide group having 5 to 7 carbon atoms.
12,13-Dihydro-1,11-dihydroxy-13-(.beta.-D-glucopyranosy l)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, or 12,13-dihydro-1,11-dihydroxy-13-(.beta.-D-galactopyranosyl)-5H-indolo[2,3- a]pyrrolo[3,4c]carbazole-5,7(6H)-dione.
A BE-13793C derivative of the formula (IA) or a pharmaceutically acceptable salt thereof ##STR5## wherein R" is ribosyl, arabinosyl, xylosyl, lyxosyl, allosyl, altrosyl, glucosyl, mannosyl, gulosyl, idosyl, galactosyl, talosyl or 7-sedoheptulosyl.
Dependencies are inferred from the claim text.