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US 5,478,811 AGranted
Orally-active elastase inhibitors
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsNorton P. Peet, Michael R. Angelastro, Joseph P. Burkhart
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Abstract
This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases and emphysema.
Claims8
A compound having the formula ##STR22## wherein B is a group of the formulae ##STR23## P.sub.1 is Nva or Val;
- P.sub.2 is Pro;
- P.sub.3 Ile, Val or Ala;
- P.sub.4 is Ala or a bond;
- and
- X is N;
- or a hydrate or pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.