Peptide amides, processes for the preparation thereof and agents containing these as fibrin/thrombin clotting inhibitors

A peptide amide having the Formula I

• GPRP--X--NR.sub.1 --R.sub.2 I
• where G is the amino acid glycine, P is the amino acid proline, R is the amino acide arginine, X is an amino acid selected from the group consisting of Ala, Gly, Ile, and Val (SEQ ID NOS:
• 3, 14, 11, and 10, respectively);
• N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms.

The peptide amide GPRPA--NH.sub.2 (SEQ ID NO:

• 3), GPRPS--NH.sub.2 (SEQ ID NO:
• 4), GPRPG--NH.sub.2 (SEQ ID NO:
• 7), GPRPV--NH.sub.2 (SEQ ID NO:
• 10), GPRPI--NH.sub.2 (SEQ ID NO:
• 11), GPRPD--NH.sub.2 (SEQ ID NO:
• 12), GPRPE--NH.sub.2 (SEQ ID NO:
• 13), GPRPG--NH(ethyl) (SEQ ID NO:
• 14), GPRPG--N(ethyl).sub.2 (SEQ ID NO:
• 14), GPRPS--NH(isopropyl) (SEQ ID NO:
• 15), GPRPG--NH(butyl) (SEQ ID NO:
• 14), GPRPPP--NH.sub.2 (SEQ ID NO:
• 16), GPRPGG--NH.sub.2 (SEQ ID NO:
• 17), GPRPPR--NH.sub.2 (SEQ ID NO:
• 18), GPRPPP--NH(isopropyl) (SEQ ID NO:
• 16), GPRPAG--NH.sub.2 (SEQ ID NO:
• 20) or GPRPGG--NH.sub.2 (SEQ ID NO:
• 21).