Loading patent…
AssigneeThe Scripps Research Institute
InventorsBenjamin F. Cravatt, Jon A. Ashley, Kim D. Janda, Dale L. Boger, Richard A. Lerner
Estimating the term…
A process is disclosed by which a substrate is catalytically converted to a cis olefin via a syn elimination reaction. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to a bicyclo[2.2.1]heptane or bicylo[2.2.2]octane compound that is an analogue to the substrate having its bulky substituents in eclipsed positions. The chemical reaction is carried out in an aqueous medium. The catalyst molecules and hybridoma cells that secrete those molecules are also contemplated, as is a process for using cyclopentadiene or cyclohexadiene to prepare a hapten used to induce production of the catalyst molecules.
A process for carrying out a syn elimination to form a cis olefin that comprises the steps of:
A process for carrying out a syn elimination to form a cis olefin that comprises the steps of:
Hybridoma cells that secrete catalytic monoclonal antibody molecules that immunoreact with:
A process for using cyclohexadiene or cyclopentadiene to form a hapten containing eclipsed substituent groups useful for inducing production of paratopic molecules that catalyze the syn elimination of an acyclic substrate ligand of formula I ##STR45## wherein R.sup.1 is a substituent containing a five- or six-membered ring or a chain of atoms long enough to fold to approximate the structure of a five- or six-membered ring;
Dependencies are inferred from the claim text.