Powders for inhalation
AssigneeBoehringer Ingelheim GmbH
InventorsKlaus Arnold, Peter Grass, Adolf Knecht, Robert Roos, Gerhard Sluke, Herbet Thieme, Joachim Wenzel
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Abstract
In order to control and optimize the amount of inhalable active substance released when drugs are administered as inhalation powders, the invention calls for the use of auxiliaries consisting of mixtures of coarser particles (average particle size>20 .mu.m) and finer particles (average particle size<10 .mu.m).
Claims8
Powder for inhalation comprising a micronized active substance and a physiologically acceptable excipient comprising a mixture containing a fine fraction having an average particle size in the range of less than 10 .mu.m and a coarse fraction having an average particle size in the range of from about 20 .mu.m to about 150 .mu.m, wherein the weight ratio of micronized active substance to the physiologically acceptable excipient mixture is from about 0.01:5 to 0.1:5.
Dependencies are inferred from the claim text.