Polymers having benzeneboronic acid groups and insulin complexes of same of a sugar response type

A method for treating diabetes comprising,

• administering a polymer insulin complex to a diabetic patient wherein insulin is released from said complex in response to a sugar concentration in blood of the diabetic patient,
• wherein the polymer insulin complex contains at least one polymer having benzene boronic acid groups and insulin or an insulin derivative having hydroxy groups;
• said polymer having a molecular weight between 5,000 and 300,000, the content of benzene boronic acid monomers forming said polymer having boronic acid groups being 0.1 to 30 mole % and the at least one polymer being a homopolymer or copolymer of 3-acryloylaminobenzeneboronic acid, 3-methacryloylaminobenzenebornonic acid or 4-vinybenzeneboronic acid, and
• wherein said polymer insulin complex releases 0 to 500 micrograms per milliliter of said insulin or said insulin derivative having hydroxy group in response to 0 to 500 milligrams per deciliter of sugar in the blood of said diabetic patient such that an increase in blood sugar causes an increase in said insulin or said insulin derivative being released from said polymer insulin complex.