Back to results
US 5,478,566 AGranted
Stimulation of cytokine production
OwnerRoger M. Loriainventor
Life of this patent
Estimating the term…
Abstract
3.beta.,7.beta.,17.beta.-androstenetriol (".beta.AET") may be used to increase production of IL-2 in cell culture and in the intact animal. Increase in IL-2 under stimulating effect of .beta.AET provides benefits associated with IL-2 administration without the untoward effects such as increased cortisol production.
Claims12
A method of increasing IL-2 and IL-3 levels in a mammal by administration of a composition containing an IL-2 or IL-3 elevating amount of a compound of the formula:
- ##STR2## wherein each R individually may be H, alkenyl of 2-8 carbons, alkyl of 1-8 carbons, phenylalkyl of 1-4 carbons, phenyl, or COR.sub.2 (acyl), wherein R.sub.2 is H, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, phenylalkyl wherein the alkyl has 1-4 carbons or phenyl wherein the phenyl moiety may have up to three substituents chosen from among hydroxy, carboxy of 1-4 carbons, halo, alkoxy of 1-4 carbons, alkyl of 1-4 carbons, or alkenyl of 2-4 carbons and wherein any alkyl may be a straight chain, branched chain, or the alkyl may be wholly or partially cyclized.
Dependencies are inferred from the claim text.