15-deoxyspergualin analogs, their method of preparation and their use in therapeutics
AssigneeFournier Industrie et Sante
InventorsPatrice Renaut, Luc Lebreton, Patrick Dutartre, Philippe Derrepas, Soth Samreth
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Abstract
The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin. These novel compounds have the formula ##STR1## in which: n is equal to 6 or 8 and A is a single bond, CH.sub.2, CHF, CH(OH), CH(OCH.sub.3), CH.sub.2 NH or CH.sub.2 O, and their addition salts.
Claims19
A compound belonging to the family of 15-deoxyspergualin analogs, which is selected from the group consisting of:
- (i) the compounds of the formula ##STR25## in which:
- n is equal to 6 or 8 and
- A is a bond, a group CH.sub.2, a group CH(OH), a group CHF, a group CH(OCH.sub.3), a group CH.sub.2 NH or a group CH.sub.2 O, and
- (ii) their nontoxic addition salts.
2-[[[4-[ [3-(Amino)propyl]amino]butyl]amino]carbonyloxy]-N-[6-[(aminoiminomethyl)ami no]hexyl]acetamide or its addition salt with a mineral or organic acid.
N-[4-[[3-(Amino)propyl]amino]butyl]-N'-[6-[(aminoiminomethyl)amino]h exyl]propanediamide or its addition salt with a mineral or organic acid.
Dependencies are inferred from the claim text.