Amino-substituted benzenesulfonylureas and -thioureas and their use as pharmaceuticals

A substituted benzenesulfonylurea or -thiourea I ##STR18## in which:

• R(1) is hydrogen, (C.sub.1 -C.sub.6) alkyl, (CH.sub.2).sub.r --C.sub.p F.sub.2p+1, (C.sub.3 -C.sub.6)-cycloalkyl, (C.sub.1 -C.sub.2)-alkyl-(C.sub.3 -C.sub.5)-cycloalkyl or (C.sub.2 -C.sub.6)-alkenyl;
• r is zero, 1, 2, 3, 4 or 5;
• p is 1, 2, 3, 4, 5 or 6;
• R(2) is NR(3)R(4),
• R(3) and R(4) together are
• a (CH.sub.2).sub.2-7 chain in which, for a chain length of 4 to 7, one of the CH.sub.2 group can be replaced by oxygen, sulfur or NR(5), where there must be at least one CH.sub.2 group between the N atom of the NR(3)R(4) and the oxygen, sulfur or NR(5);
• or
• R(3), R(4) and R(5), independently of one another, are
• hydrogen, (C.sub.1 -C.sub.6) alkyl, (CH.sub.2).sub.r --C.sub.p F.sub.2p+1, (C.sub.3 -C.sub.6)-cycloalkyl, (C.sub.1 -C.sub.2)-alkyl-(C.sub.3 -C.sub.5)-cycloalkyl or (C.sub.2 -C.sub.6)-alkenyl;
• r is zero, 1, 2, 3, 4 or 5;
• p is 1, 2, 3, 4, 5 or 6;
• E is oxygen or sulfur;
• Y is a hydrocarbon chain of the formula --[CR(6).sub.2 ].sub.n --;
• R(6) is hydrocarbon or (C.sub.1 -C.sub.2)-alkyl;
• n is 1, 2, 3 or 4;
• X is hydrogen, F, Cl, Br, I or (C.sub.1 -C.sub.6)-alkyl;
• and
• Z is F, Cl, Br, I, NO.sub.2, (C.sub.1 -C.sub.4)-alkoxy or (C.sub.1 -C.sub.4);
• alkyl,
• or the physiologically acceptable salt thereof.