Stable topical formulations with good active ingredient release characteristics, containing at least one lipophilized macrolide antibiotic
AssigneeRoehm Pharma GmbH
InventorsWolfgang A. Wohlrab, Reinhard Neubert, Sabine Matschiner, Katrin Wellner
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Abstract
A stable topical formulation with good active ingredient release characteristics, comprising at least one macrolide antibiotic which is lipophilized with at least one former of oppositely charged ions which is selected from the group consisting of alkyl sulfates, alkylsulfonates, and alkyl salicylates, RX, where R represents a linear and/or branched alkyl group with 6-32 C atoms, and X represents a sulfate, sulfonate, or salicylate group.
Claims5
A stable topical formulation with good active ingredient release characteristics, which comprises a therapeutically effective amount of one or more 14-membered lactone ring macrolide antibiotics which are lipophilized with octadecyl sulfonate.
A stable topical formulation with good active ingredient release characteristics, which comprises a therapeutically effective amount of erythromycin which is lipophilized with octadecyl sulfonate.
Dependencies are inferred from the claim text.