Method and compositions for treating tumors having high tyrosinase activity
AssigneeCo Enzyme Technology Ltd.
InventorDavid Rubin
Life of this patent
Estimating the term…
Abstract
Tumor coils which have both saccharidase and tyrosinase activity are selectively treated by administration of a conjugate of a cytotoxic compound which is a substrate for tyrosinase and at least one saccharide or a pharmaceutically acceptable salt or ester thereof. Among the cytotoxic phenolic compounds which are substrates for tyrosinase which can be used are 4-hydroxyanisole, butylated hydroxyanisole, L-3,4-dihydrophenylalanine, dopamine, tertbutylcatechol, hydroquinone, resorcinol, 6-hydroxydopa, and methyl gallate. The efficacy of the treatment is enhanced by also administering a compound that inhibits the action of glutathione reductase.
Claims25
In a method of selectively treating tumor cells which have both saccharidase and tyrosinase activity, the improvement comprising administering to a patient in need thereof an effective amount to treat said tumor cells without adversely affecting surrounding normal cells at least one conjugate made by conjugating a mono or di saccharide or a pharmaceutically acceptable ester or salt thereof to a cytotoxic phenolic compound which is also a substrate for tyrosinase.
A composition for treating tumor cells which have both saccharidase activity and tyrosinase activity with a cytotoxic phenolic compound, the improvement comprising an active ingredient made by conjugating at least one mono or di saccharide compound selected from the group consisting of mono or di saccharides and pharmaceutically acceptable esters and salts thereof to a cytotoxic phenolic compound which is also a substrate for tyrosinase, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.