Compositions for topical application to skin, hair and nails
AssigneeElizabeth Arden Co., Division of Conopco, Inc.
InventorsSreekumar Pillai, Suk H. Cho, Anthony V. Rawlings
Life of this patent
Estimating the term…
Abstract
Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.
Claims5
A composition for topical application to human skin, hair or nails, the composition comprising:
- i) from about 0.000001 to about 10 wt. % of 25-hydroxycholecalciferol;
- ii) from about 0.0001 to about 50 wt. % of a lipid material selected from the group consisting of ceramides, pseudoceramides, neoceramides, and mixtures thereof wherein ceramides have structure (II):
- ##STR11## where A represents --CH.dbd.CH--;
- R is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sub.1 is a linear, saturated aliphatic hydrocarbon group having from 8 to 20 carbon atoms;
- R.sub.3 is hydrogen;
- R.sub.4 is a hydrogen;
- pseudoceramides have the structure (III):
- ##STR12## where R.sub.6 is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sub.7 is a linear, saturated hydrocarbon group having from 10 to 22 carbon atoms;
- R.sub.9 is hydrogen;
- and neoceramides have the structure (IV):
- ##STR13## wherein R.sup.11 is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sup.12 is a linear, saturated aliphatic hydrocarbon group having from 7 to 24 carbon atoms;
- and
- iii) a cosmetically acceptable vehicle for 25-hydroxycholecalciferol and the lipid material.
A method of improving the appearance of wrinkled, flaky, aged, photodamaged skin, the method comprising applying topically to skin an effective amount of the composition comprising
- i) from about 0.000001 to about 10 wt. % of 25-hydroxycholecalciferol;
- ii) from about 0.0001 to about 50 wt. % of a lipid material selected from the group consisting of ceramides, pseudoceramides, neoceramides, and mixtures thereof wherein ceramides have structure (II):
- ##STR14## where A represents --CH.dbd.CH--;
- R is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sub.1 is a linear, saturated aliphatic hydrocarbon group having from 8 to 20 carbon atoms;
- R.sub.3 is hydrogen;
- R.sub.4 is a hydrogen;
- pseudoceramides have the structure (III):
- ##STR15## where R.sub.6 is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sub.7 is a linear, saturated hydrocarbon group having from 10 to 22 carbon atoms;
- R.sub.9 is hydrogen;
- and neoceramides have the structure (IV):
- ##STR16## wherein R.sup.11 is a linear, saturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms;
- R.sup.12 is a linear, saturated aliphatic hydrocarbon group having from 7 to 24 carbon atoms;
- and
- iii) a cosmetically acceptable vehicle for 25-hydroxycholecalciferol and the lipid material.
Dependencies are inferred from the claim text.