Pasteurella haemolytica leukotoxin compositions and uses thereof
AssigneeUniversity of Saskatchewan
InventorAndrew A. Potter
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Abstract
New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.
Claims8
A vaccine composition comprising P. haemolytica leukotoxin 352 (LKT 352), as depicted in FIG. 5 and a pharmaceutically acceptable vehicle.
A vaccine composition comprising a pharmaceutically acceptable vehicle, an adjuvant, P. haemolytica leukotoxin 352 (LKT 352), as depicted in FIG. 5, and a saline extract of P. haemolytica.
Isolated P. haemolytica leukotoxin 352 (LKT 352), having the amino acid sequence depicted in FIG. 5.
Dependencies are inferred from the claim text.