Process for preparing pharmaceutical compositions having an increased active substance dissolution rate, and the compositions obtained
AssigneeJagotec AG
InventorsUbaldo Conte, Aldo La Manna, Paolo Giunchedi
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Abstract
A process is described for preparing pharmaceutical compositions by co-grinding or dry mixing the active substance with cyclodextrins or with hydrophilic polymer materials which swell on contact with water. Homogeneous compositions are obtained from which the active substance is released very rapidly into an aqueous medium.
Claims4
A process for preparing a pharmaceutical tablet of terfenadine having a controlled terfenadine dissolution rate, said process consisting of co-grinding or mixing terfenadine with an agent which provides a controlled terfenadine dissolution rate and consists of cross-linked sodium carboxymethylcellulose and a hydrophilic polymer which forms a gel on contact with water, said hydrophilic polymer being selected from the group consisting of hydroxypropylmethylcellulose, hydroxylpropylcellulose, sodium carboxymethylcellulose, scleroglucan and polyvinyl alcohol, to form a mixture wherein the quantity of terfenadine used is between 1 to 90% by weight of the whole mixture, and thereafter tableting said mixture.
Dependencies are inferred from the claim text.