X-ray contrast compositions containing iodophenoxyalkanes and pharmaceutically acceptable clays
AssigneeSterling Winthrop Inc.
InventorsStephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, John L. Toner
Life of this patent
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Abstract
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
Claims20
An x-ray contrast composition for oral or retrograde examination of the gastrointestinal tract comprising on a % weight per volume basis:
- (a) from about 5 to 45% of an x-ray contrast producing agent having the formula, or a pharmaceutically acceptable salt thereof ##STR12## wherein R is a substituted or unsubstituted alkyl group containing from 2 to 8 carbon atoms, wherein said substituents are selected from the group consisting of C.sub.1 -C.sub.6 alkyl, hydroxy and alkoxy;
- and n is 1 to 5;
- (b) from about 0.1 to 10% of a pharmaceutically acceptable clay selected from the group consisting of:
- montmorillonite, beidelite, nontronite, hectorite and saponite;
- (c) from about 1.0 to 20% of a surfactant selected from the group consisting of nonionic, anionic, cationic and zwitterionic surfactants;
- (d) from about 0 to 15% of an excipient;
- and
- (e) water to make 100% by volume.
A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral or rectal administration to the patient an x-ray contrast formulation comprising:
- (a) from about 5 to 45% of an x-ray contrast producing agent having the formula, or a pharmaceutically acceptable salt thereof ##STR15## wherein R is a substituted or unsubstituted alkyl group containing from 2 to 8 carbon atoms, wherein said substituents are selected from the group consisting of C.sub.1 -C.sub.6 alkyl, hydroxy and alkoxy;
- and n is 1 to 5;
- (b) from about 0.1 to 10% of a pharmaceutically acceptable clay selected from the group consisting of montmorillonite, beidelite, nontronite, hectorite and saponite;
- (c) from about 1.0 to 20% of a surfactant selected from the group consisting of nonionic, anionic, cationic and zwitterionic surfactants;
- (d) from about 0.0 to 15% of an excipient;
- and
- (e) water to make 100% by volume.
Dependencies are inferred from the claim text.