Anticalcification treatment for aldehyde-tanned biological tissue
AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorsEli Seifter, Robert W. M. Frater
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Abstract
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having the formula: ##STR1## where R is CH.sub.2 OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C.sub.2 -C.sub.9 or a carboxyalkyl; or ##STR2## where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.
Claims7
A method of treating glutaraldehyde-tanned biological tissue for use in bioprosthetic valves and the like to minimize in vivo calcification and reduce cytotoxicity of the tanned tissue without impairing the mechanical strength of the tanned tissue, comprising the step of:
- treating the glutaraldehyde-tanned biological tissue with at least substantially solvent-free 1,2-propanediol to form a 5 member ring adduct of the glutaraldehyde.
Dependencies are inferred from the claim text.