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US 5,475,232 AGranted
Method for elution of a radioisotope according to an elution run schedule
AssigneeSyncor International Corporation
InventorsWesley Powers, Jimmie C. McDonald
Life of this patent
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Abstract
A method that provides a preferred generator profile that includes a set of generators, described in terms of their size, calibration and day of receipt, that will meet radioisotope requirement for a location for a preselected period of time. The method also selects generators for elution of radioisotope and determines an elution schedule which allocates elution of the generators throughout the preselected period of time so that the radioisotope requirement is met while avoiding undue wastage of radioactivity.
Claims12
A method for elution of a radioisotope according to an elution run schedule, comprising:
- selecting a first set of generators;
- determining qualified generator profiles, wherein each qualified generator profile includes a second set of generators, selected from the first set of generators, such that the generators in each qualified generator profile are capable of producing, by time and amount, an output of radioisotope not less than an amount of radioisotope required for a preselected period of time;
- determining a preferred generator profile from the list of qualified generator profiles;
- determining an elution run schedule that designates the group of generators from the preferred generator profile to elute during each elution run performed during the preselected period of time;
- and
- eluting one or more of the group of generators in the preferred generator profile designated by the elution run schedule.
3 more elements
A method for elution of a radioisotope according to an elution run schedule, comprising:
- selecting a first set of generators, including
- determining generator size criterion;
- determining generator calibration criterion;
- determining generator manufacturer criterion;
- determining generator day of receipt criterion;
- and
- assigning generators that meet the size criterion, the calibration criterion, the manufacturer criterion and the day of receipt criterion as the first set of generators;
- determining a maximum number of generators in a qualified generator profile;
- determining a set of possible generator profiles, each possible generator profile including generators selected from the first set of generators, such that the number of generators in each possible generator profile is not greater than the maximum number of generators in a profile;
- determining a list of qualified generator profiles from the set of possible generator profiles, including for each possible generator profile, determining whether the generators in the possible generator profile are capable of producing, by time and amount, an output of radioisotope not less than the amount of radioisotope required for the preselected period of time;
- determining a preferred generator profile from the list of qualified generator profiles;
- determining an elution run schedule that designates the subset of generators from the preferred generator profile to elute during each elution run performed during the preselected period of time;
- and
- eluting the group of generators in the preferred generator profile designated by the elution run schedule.
11 more elements
A method for elution of a radioisotope according to an elution run schedule, comprising:
- selecting a first set of generators, including
- determining generator size criterion;
- determining generator calibration criterion;
- determining generator manufacturer criterion;
- determining generator day of receipt criterion;
- and
- assigning generators that meet the size criterion, the calibration criterion, the manufacturer criterion and the day of receipt criterion as the first set of generators;
- determining qualified generator profiles, wherein each qualified generator profile includes a second set of generators, selected from the first set of generators, such that the generators in each qualified generator profile are capable of producing, by time and amount, an output of radioisotope not less than an amount of radioisotope required for a preselected period of time;
- determining a preferred generator profile from the list of qualified generator profiles;
- determining an elution run schedule that designates the subset of generators from the preferred generator profile to elute during each elution run performed during the preselected period of time, including
- determining elution run times for the elution runs that will be performed during the preselected period of time;
- for each elution run, determining generators for use in the elution run by
- determining a radioisotope requirement of the elution run;
- determining the level of available radioisotope in each generator in the preferred generator profile;
- determining a subset of generators in the preferred generator profile with a total amount of available radioisotope that is not less than the radioisotope requirement of the elution run, and with the least amount of available radioisotope remaining in the subset of generators after the radioisotope requirement of the elution run has been subtracted from total amount of radioisotope available in the subset;
- and
- assigning the determined subset set of generators as the generators designated for use in the elution run;
- and
- eluting the group of generators in the preferred generator profile designated by the elution run schedule for use in the elution run.
16 more elements
Dependencies are inferred from the claim text.