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US 5,475,139 AGranted
Method for the preparation of substituted derivatives of diphenyl amine
AssigneeYung Shin Pharm. Ind. Co., Ltd.
InventorsFangchen Lee, Tsung-Chung Liu
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Abstract
This invention provides a novel process for the preparation of substituted derivatives of diphenyl amine. The special feature of this novel process is that low cost and recoverable phenolic salts are used as catalysts for molecular rearrangement and aminolysis to obtain substituted derivatives of diphenyl amine in high yield.
Claims9
A method for the preparation of substituted derivatives of diphenyl amine having the structure of formula I ##STR5## comprising:
- (a) dissolving an N-phenyl phenoxy acetamide having the structure of formula (II) in a polar aprotic solvent ##STR6## (b) adding at least one metallic phenol salt having the structure of formula (III) and reacting at reaction temperature, ##STR7## wherein Y.sub.1, Y.sub.2 and Y.sub.3 are same or different and each individually represents a halogen;
- C.sub.1-4 alkyl group or hydrogen, Z.sub.1, Z.sub.2, and Z.sub.3 are same or different and each individually represents a C.sub.1-4 alkyl group;
- R.sub.1, R.sub.2 and R.sub.3 are same or different and each individually represents a C.sub.1-4 alkyl group, amino group, and methoxy group, and M represents an alkali metal.
Dependencies are inferred from the claim text.