Anilide derivative
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsMasakazu Sato, Yutaka Kawashima, Katsuo Hatayama
Life of this patent
Estimating the term…
Abstract
An anilide derivative useful as an atherosclerosis treating drug, represented by the following formula (I): ##STR1## wherein X is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; Y is a hydrogen atom or an alkoxy group having 1 to 4 carbon atoms; Z is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; A is an alkylene group having 1 to 4 carbon atoms; R is an alkyl group having 6 to 20 carbon atoms, an alkanoyl group having 2 to 20 carbon atoms or a benzyl group which may be substituted with an alkyl group having 1 to 4 carbon atoms; and n is 0, 1 or 2.
Claims19
A compound represented by the following formula (I):
- ##STR6## wherein X is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms;
- Y is a hydrogen atom or an alkoxy group having 1 to 4 carbon atoms;
- Z is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms;
- A is an alkylene group having 1 to 4 carbon atoms;
- R is an alkyl group having 6 to 20 carbon atoms, an alkanoyl group having 2 to 20 carbon atoms or a benzyl group which may be substituted with an alkyl group having 1 to 4 carbon atoms;
- and n is 0, 1 or 2.
A method of treating arteriosclerosis, comprising the steps of:
- administering to a patient in need thereof an effective amount of a compound represented by formula (I):
- ##STR7## wherein X is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- Y is a hydrogen atom or an alkoxy group having from 1-4 carbon atoms;
- Z is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- A is an alkylene group having from 1-4 carbon atoms;
- R is an alkyl group having from 6-20 carbon atoms, an alkanoyl group having 2-20 carbon atoms or a benzyl group which may be substituted with an alkyl group having from 1-4 carbon atoms;
- and n is 0, 1, or 2.
A method of inhibiting acyl-coenzyme A cholesterol acyl transferase, comprising the steps of:
- administering to a patient in need thereof an effective amount of a compound represented by formula (I):
- ##STR8## wherein X is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- Y is a hydrogen atom or an alkoxy group having from 1-4 carbon atoms;
- Z is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- A is an alkylene group having from 1-4 carbon atoms;
- R is an alkyl group having from 6-20 carbon atoms, an alkanoyl group having 2-20 carbon atoms or a benzyl group which may be substituted with an alkyl group having from 1-4 carbon atoms;
- and n is 0, 1, or 2.
A pharmaceutical composition, comprising:
- a compound represented by formula (I):
- ##STR9## wherein X is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- Y is a hydrogen atom or an alkoxy group having from 1-4 carbon atoms;
- Z is an alkyl group having from 1-4 carbon atoms or an alkoxy group having from 1-4 carbon atoms;
- A is an alkylene group having from 1-4 carbon atoms;
- R is an alkyl group having from 6-20 carbon atoms, an alkanoyl group having 2-20 carbon atoms or a benzyl group which may be substituted with an alkyl group having from 1-4 carbon atoms;
- and n is 0, 1, or 2;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.