Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsTerrence R. Burke, Jr., Mark S. Smyth, Benjamin B. Lim
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Abstract
The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard solid-phase or solution-phase techniques.
Claims3
The compound methyl 4-(((di-ethoxy)phosphono)difluoromethyl)-N-(tertiary butoxycarbonyl)-D,L-phenylalaninate.
The compound 4-(((di-ethoxy)phosphono)difluoromethyl)-N-(tertiary butoxycarbonyl)-D,L-phenylalanine.
The compound 4-(((di-ethoxy)phosphono)difluoromethyl)-N-(fluorenylmethoxycarbonyl)-D,L- phenylalanine.
Dependencies are inferred from the claim text.