Pyrazolotriazole derivatives
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsToshio Okazaki, Akira Suga, Toshihiro Watanabe, Kazumi Kikuchi, Osamu Inagaki, Isao Yanagisawa
Life of this patent
Estimating the term…
Loading patent…
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsToshio Okazaki, Akira Suga, Toshihiro Watanabe, Kazumi Kikuchi, Osamu Inagaki, Isao Yanagisawa
Estimating the term…
This invention relates to a pyrazolotriazole derivative represented by the general formula: ##STR1## wherein each symbol means as follows; R.sup.1, R.sup.3 and R.sup.4 : one of them represents hydrogen, tetrazolylated biphenylmethyl or lower alkyl, R.sup.2 : hydrogen, tetrazolylated biphenylmethyl, cycloalkyl or lower alkyl, and R.sup.5 and R.sup.6 : these may be the same or different from each other, and each represents hydrogen, halogen, tetrazolylated biphenylmethyl, formyl, carboxyl, esterified carboxyl, cycloalkyl, lower alkoxy, lower alkoxycarbonyl, or lower alkyl which may be substituted with hydroxyl, formyl or carboxyl, provided that at least one of R.sup.1 to R.sup.6 is tetrazolylated biphenylmethyl, and the broken lines mean that the pyrazolotriazole ring forms three double bonds, or a pharmaceutically acceptable salt thereof, and to a process for the production thereof, wherein the above compound (I) is useful for treating various diseases caused by the physiological function of angiotensin II.
A pyrazolotriazole derivative represented by the general formula:
A pharmaceutical composition containing as the active ingredient a pyrazoiotriazole derivative represented by the general formula:
A pharmaceutical composition containing as the active active ingredient 2,7-diethyl-5-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b] [1,2,4]triazole-6-carboxylic acid or an ester thereof.
Dependencies are inferred from the claim text.