Method for producing substituted pyridine derivatives
AssigneeIshihara Sangyo Kaisha, Ltd.
InventorsTakao Awazu, Hiroshi Okada, Masamitsu Matsumoto
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Abstract
A method for producing a substituted pyridine derivative of the formula (II): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom, a halogen atom or an alkyl group, and m is an integer of from 1 to 3, which comprises reducing a substituted trichloromethylpyridine derivative of the formula (I): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with use of acetic acid, hydrochloric acid or sulfuric acid, as a proton donor, and zinc, tin or a mixture thereof, as a reducing agent.
Claims13
A method for producing a substituted pyridine derivative of the formula (II):
- ##STR6## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom a halogen atom or an C.sub.1-6 alkyl group, which comprises:
- reducing a substituted trichloromethylpyridine derivative of the formula (I):
- ##STR7## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with hydrochloric acid or sulfuric acid, as a proton donor, zinc, as a reducing agent, and methanol, or ethanol as a solvent.
A method for producing 2-chloro-5-chloromethylpyridine, which comprises:
- reducing 2-chloro-5-trichloromethylpyridine at a reaction temperature of from -20.degree. C. to 100.degree. C. in the presence of from 2 to 4 equivalents of sulfuric acid as the proton donor and from 2 to 4 equivalents of zinc, each relative to 1 mol of 2-chloro-5-trichloromethylpyridine, in from 0.5 to 50 parts by weight of methanol as the solvent.
A method for producing 2-chloro-5-chloromethylpyridine, which comprises:
- reducing 2-chloro-5-trichloromethylpyridine at a reaction temperature of from -20.degree. C. to 100.degree. C. in the presence of from 2 to 4 equivalents of hydrochloric acid as the proton donor and from 2 to 4 equivalents of zinc, each relative to 1 mol of 2-chloro-5-trichloromethylpyridine in from 0.5 to 50 parts by weight of methanol as the solvent.
Dependencies are inferred from the claim text.