Neurotrophic peptides
AssigneeBoard of Regents, The University of Texas System
InventorJ. Regino Perez-Polo
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Abstract
The present invention involves peptides derived from nerve growth factor receptor protein. Such peptides are characterized by competing for NGF binding to NGF receptor at high concentrations while accentuating NGF binding at low concentrations. Preferred peptides include Cys-Glu-Glu-Cys-Pro-Glu-OH, Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH, Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH and Cys-Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH.
Claims3
A peptide having the structure Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH.
A peptide having the structure Cys-Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH.
A peptide having the structure Tyr-Cys-Gln-Asp-Lye-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH.
Dependencies are inferred from the claim text.