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US 5,475,087 AGranted
Antagonists of human granulocyte-macrophage colony stimulating factor derived from the carboxyl terminus
AssigneeSchering Corporation
InventorsGail F. Seelig, Julie E. Scheffler, Paul P. Trotta
Life of this patent
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Abstract
Antagonists of GM-CSF are disclosed that comprise antibodies and anti-idiotypic antibodies specific for the carboxyl terminus of GM-CSF. These antagonists are useful for treating various diseases, the symptoms of which are increased by GM-CSF, and for lessening the effects of chemotherapy.
Claims2
A polypeptide having an amino acid sequence:
- ##STR4## or a subsequence thereof wherein the polypeptide has from about 18 to about 23 amino acid residues such that antibodies having GM-CSF antagonistic activity can be raised against said polypeptide.
A polypeptide which has an amino acid sequence selected from the group consisting of ##STR5##
Dependencies are inferred from the claim text.