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US 5,475,085 AGranted
Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
AssigneeMolecumetics, Ltd.
InventorMichael Kahn
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Abstract
The invention provides materials and methods for synthesizing novel reverse turn mimetics, as well as peptides containing the same. Also provided are novel synthetic nonpeptide therapeutic molecules designed upon the interactions between reverse turn mimetics or peptides containing the same, and receptors, antibodies, or enzymes.
Claims8
A beta-turn mimetic having the structure:
- ##STR51## wherein X is a linker moiety;
- Y is selected from --CH.sub.2 --, --NH-- and --N(CH.sub.3)--;
- Z is hydrogen or methyl;
- and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are individually selected from naturally occuring amino acid side chain substituents.
1 more element
A beta-turn mimetic having the structure:
- ##STR56## where X is a linker moiety;
- and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are individually selected from naturally occuring amino acid side chain substituents.
Dependencies are inferred from the claim text.