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US 5,475,034 AGranted
Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
AssigneeAlcon Laboratories, Inc.
InventorsJohn M. Yanni, Gustav Graff, Mark R. Hellberg
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Abstract
Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.
Claims7
A method of treating ophthalmic inflammatory disorders and ocular pain which comprises topically administering to the eye a pharmaceutical composition comprising an anti-inflammatory-effective amount of a 3-benzoylphenylacetic acid derivative of the formula:
- ##STR7## R=H, C.sub.1-4 (un)branched alkyl, CF.sub.3, or SR.sup.4, Y=NR"R',
- R'=H, or C.sub.1-10 (un)branched alkyl, (un)substituted (substitution as defined by X below),
- R"=H,
- X and X' independently=H, F, Cl, Br, I, OR', OH, SR.sup.4, CF.sub.3, R.sup.4, or NO.sub.2,
- R.sup.4 =C.sub.1-6 (un)branched alkyl,
- m=0-3,
- m'=0-5, and
- W=H.
5 more elements
Dependencies are inferred from the claim text.