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US 5,475,029 AGranted
Farnesyl compounds as cholesterol lowering agents
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDavid L. Bradfute, Robert D. Simoni
Life of this patent
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Abstract
Farnesyl derivatives, particularly farnesyl acetate, are used to lower the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in cells, thereby reducing cholesterol biosynthesis. The compounds may be administered to hypercholesterolemia patients to reduce the overall level of serum cholesterol, either alone or in conjunction with other drugs conventionally used for the treatment of hypercholesterolemia.
Claims4
A method for treating a patient for hypercholesterolemia, said method comprising:
- administering to said patient an amount effective to reduce the level of serum cholesterol, of a compound of the formula:
- ##STR5## where R.sub.1 is a lower alkyl of from 1 to 4 carbon atoms, or an acyl group ##STR6## where R.sub.2 is a lower alkyl of from 1 to 4 carbon atoms.
Dependencies are inferred from the claim text.