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US 5,475,024 AGranted
Benzodioxole derivatives
AssigneeEisai Co., Ltd.
InventorsYoshitake Ogata, Makoto Ikeda, Seiichiro Nomoto, Makoto Okita, Naoyuki Shimomura, Toshihiko Kaneko, Takashi Yamanaka, Ieharu Hishinuma, Junichi Nagakawa, Kazuo Hirota, Kaname Miyamoto, Toru Horie, Tsuneo Wakabayashi
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Abstract
A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
Claims8
A benzodioxole derivative having the formula (I) or a pharmacologically acceptable salt thereof:
- ##STR363## wherein T, U, V and W are defined according to group (i) or (ii):
- (i) T is hydrogen, U is hydrogen, V is hydrogen, and W is --(CH.sub.2).sub.2 --X--R
- wherein X represents a group of the formula:
- ##STR364## and R represents:
- (1) a group of the formula (CH.sub.2).sub.n --COOR.sup.1 in which n represents an integer of 1 to 5 and R.sup.1 represents a hydrogen atom or a lower alkyl group,
- (2) a group of the formula --(CH.sub.2).sub.n --CONR.sup.3 R.sup.4 in which n represents an integer of 1 to 5 and R.sup.3 and R.sup.4, which may be the same or different, each represents a hydrogen atom, a lower alkyl group or a carboxymethyl group;
- (ii) T and U, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, V represents a hydrogen atom, a lower alkyl group, or a group of the formula --(CH.sub.2).sub.2 COOH in which z represents an integer of 1 to 3, and W represents a group of the formula:
- --CH.sub.2 --CR.sup.5 R.sup.6 --A--Z
- wherein R.sup.4 and R.sup.6 may be the same or different and each represents a hydrogen atom or a lower alkyl group, X represents ##STR365## and A represents CR.sup.7 R.sup.8 -COOH in which R.sup.7 and R.sup.8 may be the same or different and each represents a hydrogen atom or a lower alkyl group.
6 more elements
Dependencies are inferred from the claim text.