1,5-diphenyl pyrazole compounds for treatment of inflammation
AssigneeG. D. Searle & Co.
InventorsLen F. Lee, Stephen R. Bertenshaw
Life of this patent
Estimating the term…
Abstract
A class of 1,5-diphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is methylsulfonyl; wherein R.sup.2 is selected from --CF.sub.3, --CF.sub.2 Cl, --CF.sub.2 H, --CF.sub.2 CF.sub.3 and --CF.sub.2 CF.sub.2 CF.sub.3 ; and wherein R.sup.3 is fluoro or chloro; or a pharmaceutically-acceptable salt thereof.
Claims19
A compound of Formula II ##STR7## wherein R.sup.1 is methylsulfonyl;
- wherein R.sup.2 is selected from --CF.sub.3, --CF.sub.2 Cl, --CF.sub.2 H, --CF.sub.2 CF.sub.3 and --CF.sub.2 CF.sub.2 CF.sub.3 ;
- wherein R.sup.3 is hydrido or halo;
- or a pharmaceutically-acceptable salt thereof.
A pharmaceutical composition comprising a therapeutically-effective amount of a compound and a pharmaceutically-acceptable carrier or diluent, said compound selected from a family of compounds of Formula II ##STR8## wherein R.sup.1 is methylsulfonyl;
- wherein R.sup.2 is selected from --CF.sub.3, --CF.sub.2 Cl, --CF.sub.2 H, --CF.sub.2 CF.sub.3 and --CF.sub.2 CF.sub.2 CF.sub.3 ;
- wherein R.sup.3 is halo or hydrido;
- or a pharmaceutically-acceptable salt thereof.
A method of treating inflammation or an inflammation-associated disorder, said method consisting of administering to a subject having said inflammation or said inflammation-associated disorder, a therapeutically-effective amount of a compound of Formula II ##STR9## wherein R.sup.1 is methylsulfonyl;
- wherein R.sup.2 is selected from --CF.sub.3, --CF.sub.2 Cl, --CF.sub.2 H, --CF.sub.2 CF.sub.3 and --CF.sub.2 CF.sub.2 CF.sub.3 ;
- wherein R.sup.3 is hydrido or halo;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.