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US 5,475,017 AGranted
Diaryl-substituted heterocyclic compounds, drugs and cosmetics obtained therefrom
AssigneeBASF SE
InventorsHans-Heiner Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell
Life of this patent
Estimating the term…
Abstract
Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.
Claims8
Compounds of the formula I ##STR43## where R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is ##STR44## R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group, R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,
- R.sup.5 is hydrogen, methoxy or tert-butyl,
- R.sup.6 is hydrogen, methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the group --CHR.sup.7 OR.sup.8, --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR45## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,
- R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.20 -alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine,
- R.sup.9 and R.sup.10 are each hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.6 -alkanoyl or are each benzoyl which is unsubstituted or substituted as for R.sup.8, or R.sup.9 and R.sup.10, together with the nitrogen atom to which they are bonded, form a saturated, 5-membered or 6-membered heterocyclic group which may contain oxygen as the second heteroatom,
- R.sup.11 is hydrogen, C.sub.1 -C.sub.4 -alkyl, --OR.sup.13 or --NR.sup.14 R.sup.15, where R.sup.13 is hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.8 -alkyl, aryl or aralkyl which is unsubstituted or substituted by chlorine, bromine, methyl, methoxy or nitro, substitution in the case of the aralkyl group being in the aryl moiety,and where R.sup.14 and R.sup.15 are each hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.6 -alkyl or an aralkyl or aryl group which is unsubstituted or substituted as for R.sup.13, or R.sup.14 and R.sup.15, together with the nitrogen atom to which they are bonded, form a heterocyclic group as defined above for R.sup.9 and R.sup.10, and R.sup.12 is C.sub.1 -C.sub.4 -alkyl, or their physiologically tolerated salts.
2 more elements
Dependencies are inferred from the claim text.