N-cyanoamidine derivatives as anti-influenza agents
AssigneeAmerican Home Products Corporation
InventorsKuo-Hom L. Hsu, Daniel M. Teller, Alan R. Davis, Michael D. Lubeck, Harry R. Munson, Jr., Gunnar E. Jagdmann, Ibrahim M. Uwaydah
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Abstract
Antiinfluenza A activity was found in compounds of the formula: ##STR1## wherein: X is 2-phenylethyl, 2-furanylmethyl, or ##STR2## where one of R.sup.1 and R.sup.2 is H and the other is phenylamino; Z is --SCH.sub.3 when X is ##STR3## or ##STR4## when X is 2-phenylethyl or 2-furanylmethyl; or a pharmaceutically acceptable salt thereof.
Claims3
A compound of the formula:
- ##STR11## wherein:
- X is 2-furanylmethyl and
- Z is ##STR12## or a pharmaceutically acceptable salt thereof.
A method of treating influenza A infections in mammals which comprises administration to the mammal in need thereof a therapeutically effective amount of a compound of the formula:
- ##STR13## wherein:
- X is 2-furanylmethyl and
- Z is ##STR14## or a pharmaceutically acceptable salt thereof
A pharmaceutical composition for treating influenza A infection in mammals comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the formula:
- ##STR15## wherein:
- X is 2-furanylmethyl and
- Z is ##STR16## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.