Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease
AssigneeHoechst Aktiengesellschaft
InventorsHolger Heitsch, Gabriele Wiemer, Adalbert Wagner, Heinz-Werner Kleemann
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Abstract
Antagonists for angiotensin II receptors of the AT.sub.1 subtype can be employed for the prophylaxis and combating of coronary heart disease. Furthermore these compounds, such as, for example, azoles of the formula (I) ##STR1## can also be used for the therapy of cognitive and erectile dysfunction.
Claims4
A method for the treatment of prophylaxis coronary heart disease in a mammal comprising the step of administering to a mammal in recognized need thereof an effective amount of an antagonist for angiotensin II receptors of the AT.sub.1 subtype of the formula ##STR64## in which:
- R(1) is (C.sub.1 -C.sub.7)-alkyl, (C.sub.3 -C.sub.7)-alkenyl or (C.sub.3 -C.sub.7)-alkynyl;
- R(2) and R(3) are the same or different and are hydrogen or (C.sub.1 -C.sub.4)-alkyl;
- R(15) is --SO--NR(18)--CO--OR(17), --SO.sub.2 --NR(18)--CO--NHR(16), --SO.sub.2 --NH--CO--R(17) or tetrazoyl;
- R(16) and R(17) are the same and are (C.sub.1 -C.sub.4)-alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, phenyl or phenyl-(C.sub.1 -C.sub.4)-alkyl;
- and
- R(18) is hydrogen or (C.sub.1 -C.sub.6)-alkyl;
- or a physiologically tolerable salt thereof.
The method as claimed in claim 1, wherein
- R(1) is (C.sub.1 -C.sub.4)-alkyl;
- R(15) is --SO--NR(18)--CO--OR(17) or --SO.sub.2 --NR(18)--CO--NHR (16);
- R(16) and R(17) are the same and are (C.sub.1 -C.sub.4)-alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl;
- R (18) is hydrogen;
- and
- the other radicals are as defined in claim 16.
The method as claimed in claim 3, wherein
- R(15) is --SO.sub.2 --NR(18)--CO--NHR(16);
- and the other radicals are as defined in claim 17.
Dependencies are inferred from the claim text.