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US 5,475,003 AGranted
8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
AssigneeSyntex (U.S.A.) Inc.
InventorsRobert S. Wilhelm, Sabine Axt
Life of this patent
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Abstract
The disclosed derivatives of 8-phenylcyclopentenoquinolines and 8-phenylcyclohexenoquinolines are useful as anti-inflammatory agents, immunosuppressive agents, anti-allograft, rejection agents, anti-graft-vs-host disease agents, anti-allergic agents, bronchodilation agents, anti-autoimmune agents, and analgetic agents.
Claims21
A compound represented by the formula ##STR12## wherein:
- R.sup.1 and R.sup.2 taken together represent --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- and R.sup.3 is hydrogen;
- or
- R.sup.2 and R.sup.3 taken together represent --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- and R.sup.1 is hydrogen;
- and
- R.sup.4 is phenyl optionally mono-, di-, or tri-substituted independently with lower alkyl, lower alkoxy, hydroxy, nitro, trifluoromethyl, halo, thiol, amino, nitro, lower alkylthio, mono-lower-alkylamino, di-lower alkylamino, hydroxycarbonyl, lower alkoxycarbonyl, methylcarbonyl, hydroxysulfonyl, lower alkoxysulfonyl, lower alkylsulfonyl, lower alkylsulfinyl, cyano, tetrazoyl, carbamoyl, lower alkylcarbamoyl, di-lower alkylcarbamoyl and methylenedioxy;
- provided that no more than one methylenedioxy substituent, no more than two nitro or no more than two iodo substituents are present,
- or a pharmaceutically acceptable salt or N-oxide thereof.
4 more elements
Dependencies are inferred from the claim text.