Methods and compositions of (2R,4S) itraconazole for treating fungal yeast and dermatophyte infections
AssigneesSepracor Inc., Georgetown University
InventorsNancy M. Gray, Raymond L. Woosley
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Abstract
Methods and compositions are disclosed utilizing the optically pure (2R,4S) isomer of itraconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of itraconazole.
Claims15
A method for treating local and systemic fungal, yeast and dermatophyte infections in a human which comprises administering to a human, in need of antiinfective therapy, an amount of (2R,4S) itraconazole, or a pharmaceutically acceptable salt thereof, substantially free of its (2S,4R) stereoisomer, said amount being sufficient to alleviate said infections.
A method for treating local and systemic fungal, yeast and dermatophyte infections in a human while avoiding the concomitant liability of adverse effects associated with racemic itraconazole, which comprises administering to a human, in need of antiinfective therapy, an amount of (2R,4S) itraconazole, or a pharmaceutically acceptable salt thereof, substantially free of its (2S,4R) stereoisomer, said amount being sufficient to alleviate said infection but insufficient to cause said adverse effects.
An anti-infective composition for the treatment of a human in need of therapy for a systemic or topical fungal, yeast or dermatophyte infection which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of (2R,4S) itraconazole or a pharmaceutically acceptable salt thereof, substantially free of its (2S,4R) stereoisomer.
Dependencies are inferred from the claim text.