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AssigneeSenju Pharmaceutical Co., Ltd.
InventorsKazumi Ogata, Takahiro Sakaue, Noriko Saito, Sachiko Matsuura, Rie Nagao, Shinya Ogino
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A pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis which comprise a phosphoric acid diester of the following formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof. Since the composition of this invention inhibits the formation of free radicals in the body, it can be advantageously used for the prophylaxis and treatment of various renal disorders such as glomerulonephritis, acute renal failure, uremia, adriamycin nephrosis, puromycin nephrosis, gentamicin- and cisplatin-induced disorders of the kidney, renal impairment due to paraquat and other agricultural chemicals, and immune complex nephritis. Moreover, the composition of this invention is also of use as a dialysis solution for extracorporeal hemodialysis with the propylactic/therapeutic effect on dialysis amyloidosis.
A method for the prophylaxis and treatment of a renal disorder which comprises administering orally or parenterally to a patient in need thereof a renal disorder inhibitory effective amount of a phosphoric acid diester of the following formula:
A method for dialyzing the blood of a patient in need of such treatment which comprises employing as a dialysis solution flowing in an extracorporeal hemodialyzer a solution containing a free radical inhibitory effective amount of a phosphoric acid diester of the following formula:
Dependencies are inferred from the claim text.