5-phenylpyrrolo-1,4-benzoxazine and 5-phenylpyrrolo-1,4-benzothiazine compounds, process and intermediates for their production and pharmaceutical compositions containing them
AssigneeKali-Chemie Pharma GmbH
InventorsPatrice Demonchaux, Patrick Lenoir
Life of this patent
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Abstract
Pharmacologically active compounds of formula I ##STR1## which can be substituted in the phenyl rings and in which R.sup.1 denotes hydrogen or lower alkyl, R.sup.2 denotes hydrogen or lower alkyl, Y denotes oxygen or sulfur n represents an integer from 1 to 3 Z represents a bond, a CO group or a CH.dbd. group, Q denotes nitrogen or the CH group and R.sup.7, if Q denotes nitrogen, represents an optionally substituted pyridyl or phenyl radical or, if Q denotes the CH group, represents the N-methyl-N-(4-oxo-3H-pyrimidin-2-yl)amino group, and their acid addition salts and processes and intermediates for their preparation.
Claims10
A compound corresponding to formula I:
- in which
- R.sup.1 represents hydrogen or lower alkyl,
- R.sup.2 represents hydrogen, halogen, lower alkyl, lower alkoxy, benzyloxy or hydroxyl,
- R.sup.3 represents hydrogen, halogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.4 represents hydrogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.5 represents hydrogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.6 represents hydrogen or lower alkyl,
- Y represents oxygen or sulfur,
- n represents an integer from 1 to 3,
- Z represents a bond, a CO group or a CH.sub.2 group,
- Q represents nitrogen or a CH group, and
- R.sup.7, if Q represents nitrogen, represents a pyridyl or phenyl radical which is optionally substituted by lower alkyl or halogen, or, if Q represents a CH group, represents a N-methyl-N-(4-oxo-3H-pyrimidin-2-yl)amino group,
- or a physiologically acceptable acid addition salt thereof.
A compound corresponding to formula V:
- ##STR5## in which R.sup.8 represents lower alkyl,
- R.sup.2 represents hydrogen, halogen, lower alkyl, lower alkoxy, benzyloxy or hydroxyl,
- R.sup.3 represents hydrogen, halogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.4 represents hydrogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.5 represents hydrogen, lower alkyl, lower alkoxy or hydroxyl,
- R.sup.6 represents hydrogen or lower alkyl, represents oxygen or sulfur,
- Y represents an integer from 1 to 3,
- n represents a bond, a CO group or a CH.sub.2 group,
- Z represents nitrogen or a CH group, and
- R.sup.7 , if Q represents nitrogen, represents a pyridyl or phenyl group or a pyridyl or phenyl group substituted by lower alkyl or halogen, or, if Q represents a CH group, R.sup.7 represents a N-methyl-N-(4-oxo-3H-pyrimidin-2-yl)amino group.
Dependencies are inferred from the claim text.