Method for producing 2-keto-L-gulonic acid
AssigneeTakeda Chemical Industries, Ltd.
InventorsIkuo Nogami, Hideo Shirafuji, Masahide Oka, Takamasa Yamaguchi
Life of this patent
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Abstract
2-keto-L-gulonic acid is in high yield produced by contacting a microorganism of the genus Pseudogluconobacter, either as it is or after processing, with L-sorbose.
Claims6
A method for producing 2-keto-L-gulonic acid which comprises incubating a strain of Pseudogluconobacter saccharoketogenes selected from the group consisting of K591s, FERM BP-1130;
- TH 14-86, FERM BP-1128;
- 12-15, FERM BP 1132;
- 12-4, FERM BP-1131 and 22-3, FERM BP-1133, with L-sorbose to produce and accumulate 2-keto-L-gulonic acid and harvesting the accumulated 2-keto-L-gulonic acid.
A method for producing 2-keto-L-gulonic acid which comprises incubating a strain of Pseudogluconobacter saccharoketogenes selected from the group consisting of K591s, FERM BP-1130;
- TH 14-86, FERM BP-1128;
- 12-15, FERM BP 1132;
- 12-4, FERM BP-1131 and 22-3, FERM BP-1133 with at least one microorganism selected from the group consisting of Bacillus cereus IFO 3131;
- Bacillus licheniformis IFO 12201;
- Bacillus megaterium IFO 12108;
- Bacillus pumilus IFO 12090;
- Bacillus amyloliquefaciens IFO 3022;
- Bacillus subtilis IFO 13719;
- Pseudomonas trifolii IFO 12056;
- Pseudomonas maltophilia IFO 12692;
- Proteus inconstans IFO 12930;
- Citrobacter freundii IFO 13544;
- Enterobacter cloacae IFO 3320;
- Erwinia herbicola IFO 12686;
- Xanthomonas pisi IFO 13556 and Flavobacterium meningosepticum IFO 12535, and further with L-sorbose to produce and accumulate 2-keto L-gulonic acid and harvesting the accumulated 2-keto-L-gulonic acid.
A biologically pure culture of a microorganism selected from the group consisting of Pseudogluconobacter saccharoketogenes K591s, FERM BP-1130;
- TH 14-86, FERM BP-1128;
- 12-15, FERM BP-1132;
- 12-4, FERM BP-1131 and 22-3, FERM BP-1133.
A method for producing 2-keto-L-gulonic acid which comprises incubating Pseudogluconobacter saccharoketogenes strain 12-5, FERM BP-1129 with L-sorbose to produce and accumulate 2-keto-L-gulonic acid and harvesting the accumulated 2-keto-L-gulonic acid.
A method for producing 2-keto-L-gulonic acid which comprises incubating Pseudogluconobacter saccharoketogenes strain 12-5, FERM BP-1129, with at least one microorganism selected from the group consisting of Bacillus cereus IFO 3131;
- Bacillus licheniformis IFO 12201;
- Bacillus megaterium IFO 12108;
- Bacillus pumilus IFO 12090;
- Bacillus amyloliquefaciens IFO 3022;
- Bacillus subtilis IFO 13719;
- Pseudomonas trifolii IFO 12056;
- Pseudomonas maltophilia IFO 12692;
- Proteus inconstans IFO 12930;
- Citrobacter freundii IFO 13544;
- Enterobacter cloacae IFO 3320;
- Erwinia herbicola IFO 12686;
- Xanthomonas pisi IFO 13556 and Flavobacterium meningosepticum IFO 12535, and further with L-sorbose to produce and accumulate 2-keto-L-gulonic acid and harvesting the accumulated 2-keto-L-gulonic acid.
A biologically pure culture of the microorganism Pseudogluconobacter saccharoketogenes strain 12-5, FERM BP-1129.
Dependencies are inferred from the claim text.