Antibodies to human carboxypeptidase B and methods of use thereof
AssigneeGenentech, Inc.
InventorsDennis T. Drayna, Dan L. Eaton
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Abstract
A novel polypeptide, designated plasma carboxypeptidase B (PCPB), has been purified from human plasma. It has been cloned from a human liver cDNA library using PCR amplification. Provided herein is nucleic acid encoding PCPB useful in diagnostics and in the recombinant preparation of PCPB. PCPB is used in the preparation and purification of antibodies thereto, in the purification of plasminogen, in the inhibition of plasminogen activation by t-PA in the presence of fibrinogen, and in diagnostic assays.
Claims5
An antibody which specifically binds human carboxypeptidase B (PCPB) and does not crossreact with any of carboxypeptidase A, E, M, and N, a non-plasma derived carboxypeptidase B, and a non-mammalian carboxypeptidase.
Dependencies are inferred from the claim text.