Paucilamellar lipid vesicles
AssigneeMicro-Pak, Inc.
InventorDonald F. H. Wallach
Life of this patent
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Abstract
A new method of producing paucilamellar lipid vesicles has been developed. The vesicles are made of non-phospholipid surfactants. The paucilamellar lipid vesicles have 2-8 lipid bilayers surrounding a central cavity which may be filled with either an aqueous-based solution or an oil or wax.
Claims15
Paucilamellar lipid vesicles consisting of 2-8 lipid bilayers in the form of substantially spherical shells separated by aqueous layers, said lipid bilayers surrounding a large, substantially amorphous central cavity filled with an aqueous solution, said lipid bilayers comprising:
- a surfactant selected from a group consisting of
- polyoxyethylene fatty acid esters having the formula
- R.sub.1 --COO(C.sub.2 H.sub.4 0).sub.n H
- where R.sub.1 is a lauric, myristic, cetyl, stearic, or oleic acid residue, and n=2-10;
- and
- polyoxyethylene fatty acid ethers, having the formula
- R.sub.2 --C 0(C.sub.2 H.sub.4 0).sub.m H
- where R.sub.2 is a lauric, myristic, or cetyl acid residue, a single or double unsaturated octadecyl acid residue, or a double unsaturated eicodienoic acid residue and m ranges from 2-4.
Paucilamellar lipid vesicles consisting of 2-8 lipid bilayers in the form of substantially spherical shells separated by aqueous layers, said lipid bilayers surrounding a large, substantially amorphous central cavity filled with an aqueous solution, said lipid bilayers comprising glycerol monostearate as the primary lipid.
Paucilamellar lipid vesicles consisting of 2-8 lipid bilayers in the form of substantially spherical shells separated by aqueous layers, said lipid bilayers surrounding a large, substantially amorphous central cavity filled with an aqueous solution, said lipid bilayers comprising polyoxyethylene glyceryl monostearate with 1-10 polyoxyethylene groups as the primary lipid.
Dependencies are inferred from the claim text.