Multilayered controlled release pharmaceutical dosage form
AssigneeOrtho Pharmaceutical Corporation
InventorsPramod M. Kotwal, Stephen A. Howard
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Abstract
This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.
Claims13
A multilayered controlled release pharmaceutical dosage form for water soluble drugs comprising a plurality of coated particles each comprising:
- a core comprising an inert material which is coated or granulated with a water soluble drug active;
- a first coating layer over the drug containing core comprising a water soluble film forming polymer;
- a second coating layer over the first coating layer comprising a dispersion of a film forming polymer which forms a controlled release layer over the coated drug core;
- a third coating layer comprising a water soluble film forming polymer;
- a fourth coating layer comprising additional water soluble drug active;
- a fifth coating layer comprising a film forming mixture of a water soluble film forming polymer;
- a sixth coating layer comprising a dispersion of a film forming polymer which forms a controlled release layer over the coated drug core;
- and
- a final coating layer of a water soluble film forming polymer.
Dependencies are inferred from the claim text.